Updates & Controversies in Medication-related Osteonecrosis of the Jaws

Osteonecrosis of the jaws (MRONJ) is a devastating complication of antiresorptive medications utilized for benign and malignant disorders of bone metabolism. MRONJ is defined as exposed, necrotic bone in the maxillofacial region that has persisted for more than eight weeks in a patient with current or previous bisphosphonate treatment, without a history of radiation therapy to the jaws. ONJ was first identified in 2003 and 2004, and its prevalence is reported between 0.8-12%. Difficulties with diagnosis, prevention and treatment exist, often making dentists uncomfortable recognizing and treating patients on these medications. This lecture will discuss MRONJ risk, diagnosis, prevention, and management. Specific case discussions will also be included.